PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH CYCLIC AMINO GROUP AS CRF ANTAGONISTS Russian patent published in 2010 - IPC C07D471/04 C07D487/04 A61K31/437 A61K31/519 A61P25/00 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to novel pyrrolopyrimidine and pyrrolopyridine of general formula (I), substituted with a cyclic amino group (II), or their pharmaceutically acceptable salts having CRF antagonist properties. In general formula the cyclic amino group has formula , in which the cyclic amino group is a 6-member saturated cyclic amine, the said cyclic amine is substituted with a group of formula -(CH₂)_mX; in which X is -CO₂H, -CONH₂,-P(=O)(OH)₂ or -S(=O)₂OH; Y is N or CH; m is an integer selected from 1, 2 and 3; R⁴ is hydrogen; R⁵ is hydrogen; R⁶ is C_1-5alkyl; R⁷ and R⁸ are identical or different and independently represent hydrogen, C_1-5alkyl, Ar is phenyl which is unsubstituted or substituted with one or more substitutes which are identical or different and are selected from a group consisting of halogen, C_1-5alkyl, C_1-5alkoxy, C_1-5alkylthio, trifluoromethyl and trifluoromethoxy.

EFFECT: compounds can be used for therapeutic or preventive treatment of diseases where CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension etc.

12 cl, 6 dwg, 1 tbl, 10 ex