FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formula (IVa-2), or to their pharmaceutically acceptable salts, tautomers or deuterated analogs. In formula (IVa-2), the radicals and symbols have the definitions given in the claims. Compounds of formula (IVa-2) are active against c-kit protein kinases or c-kit mutant protein kinases having any of the mutations described herein. 
.
EFFECT: methods for the preparation and use of these compounds for the treatment of diseases and conditions associated with aberrant activity of c-kit protein kinases and / or c-kit mutant protein kinases are also described.
20 cl, 3 tbl, 26 ex
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