PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES Russian patent published in 2009 - IPC C07D487/04 A61K31/519 A61K31/53 A61P9/10 A61P25/28 

FIELD: medicine.

SUBSTANCE: invention covers new pyrrolopyrimidine and pyrrolotriazine derivatives substituted with carbamoyl group of formula [I], characterised as a CRF (corticotrophin release factor) receptor antagonist. The compounds can be effective as a therapeutic or preventive agent for such diseases, as depression, anxiety, Alzheimer's disease, Parkinson's disease, etc. in formula [I]: E means N or CR¹⁰; R¹ means -OR⁴, -S(O)₁R⁴ or-NR⁴R⁵; R² means hydrogen, C_1-6alkyl; R³ means hydrogen; R⁴ and R⁵ are identical or different, and independently mean hydrogen, C_1-9alkyl, di(C_3-7cycloalkyl)-C_1-6alkyl, C_1-6alkoxy-C_1-6alkyl, di(C_1-6alkoxy)-C_1-6alkyl, hydroxy-C_1-6alkyl, cyano-C_1-6alkyl, carbamoyl-C_1-6alkyl or di(C_1-6alkyl)amino-C_2-6alkyl, or R⁴ and R⁵ together form (CH₂)_m-A-(CH₂)_n where A means CHR⁹; R⁹ means hydrogen, hydroxy-C_1-6alkyl, or cyano-C_1-6alkyl; R₁₀ means hydrogen; I means an integer 0, 1 and 2; m means an integer 1, 2, 3 and 4; n means an integer 0, 1, 2 and 3; Ar means phenyl, and specified phenyl is substituted by one or more substitutes being identical or different, and chosen from the group consisting of halogen, C_1-6alkyl, trifluoromethyl; their individual isomers or pharmaceutically acceptable salts.

EFFECT: extended application.

9 cl, 2 dwg, 2 tbl, 2 ex