FIELD: chemistry.
SUBSTANCE: invention relates to peptides which originate from an antigen recognised by autoantibodies used for diagnosing rheumatoid arthritis. The peptides are filaggrin molecule fragments which contain modified residues of arginine and having amino acid sequences given in the formula of invention. The invention discloses a method of diagnosing rheumatoid arthritis by detecting autoimmune antibodies using the said peptide(s) through reaction of the latter with the blood serum of patients suffering from rheumatoid arthritis. Presence of autoimmune antibodies in the analysed sample is indicated by presence of peptide complexes formed with the antibody.
EFFECT: disclosed peptide has high specificity and sensitivity.
4 cl, 1 dwg, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| ANTI-OSTEOPANTINE RECOMBINANT ANTIBODY AND USES THEREOF | 2002 |
|
RU2305111C2 |
| NOVEL PEPTIDES AS AUTOANTIGEN DERIVATIVES DESIGNATED FOR USE IN IMMUNOTHERAPY OF AUTOIMMUNE DISEASES | 1995 |
|
RU2178797C2 |
| RA ANTIGEN PEPTIDES | 2004 |
|
RU2359974C2 |
| NEW PEPTIDES FOR APPLICATION IN IMMUNOTHERAPY OF AUTOIMMUNE DISEASES | 1999 |
|
RU2233290C2 |
| IMMUNOASSAY METHOD WITH INTERFERENCE SUPPRESSION FOR DETERMINATION OF ANTIBODIES FOR DRUGS IN SERUM SAMPLES | 2014 |
|
RU2674996C2 |
| ANTIBODY AGAINST OSTEOPONTIN AND ITS USING | 2002 |
|
RU2299888C2 |
| METHOD OF PREPARING MONOCLONAL ANTIBODY RAISED AGAINST T-CELLS SURFACE ANTIGEN, MONOCLONAL ANTIBODY, PHARMACEUTICAL COMPOSITION AND DIAGNOSTIC REAGENT | 1997 |
|
RU2196178C2 |
| ENZYME IMMUNOASSAY METHOD FOR DETERMINATION OF SOLUBLE FORM OF ANTIGENS HLA-DR IN HUMAN BLOOD SERUM | 2002 |
|
RU2237249C2 |
| METHOD FOR SERODIAGNOSTICS OF EARLY NEUROSYPHILIS | 2001 |
|
RU2205409C2 |
| DIAGNOSTIC TECHNIQUE FOR RHEUMATOID ARTHRITIS IF MUTATED CITRULLINATED VIMENTIN ANTIBODIES (Anti-MCV) ARE FOUND IN ORAL FLUID | 2012 |
|
RU2523413C1 |
