FIELD: chemistry.
SUBSTANCE: invention relates to peptides which originate from an antigen recognised by autoantibodies used for diagnosing rheumatoid arthritis. The peptides are filaggrin molecule fragments which contain modified residues of arginine and having amino acid sequences given in the formula of invention. The invention discloses a method of diagnosing rheumatoid arthritis by detecting autoimmune antibodies using the said peptide(s) through reaction of the latter with the blood serum of patients suffering from rheumatoid arthritis. Presence of autoimmune antibodies in the analysed sample is indicated by presence of peptide complexes formed with the antibody.
EFFECT: disclosed peptide has high specificity and sensitivity.
4 cl, 1 dwg, 3 tbl
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