NOVEL PEPTIDES THAT CAN BE USED IN ANTIGEN-SPECIFIC IMMUNOSUPPRESSIVE THERAPY Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemistry of peptides, pharmacy. SUBSTANCE: invention relates to peptides consisting of 16-55 amino acid residues being indicated peptides comprise at least one of amino acid sequence: FLCTHIIYS (SEQ ID NO:61), IIYSFANIS (SEQ ID NO:62), FIKSVPPEL (SEQ ID NO:64), FDGLDLAWL (SEQ ID NO: 65), LYPGRRDKQ (SEQ ID NO:66), YDIAKISQH (SEQ ID NO:67), LDFISIMTY (SEQ ID NO:68), FISIMTYDF (SEQ ID NO:69), FRGQEDASP (SEQ ID NO: 70), YAVGYMLRL (SEQ ID NO:71), MLRLGAPAS (SEQ ID NO:72), LAYYEICDF (SEQ ID NO: 73), LRGATVHRT (SEQ ID NO:74), YLKDRQLAG (SEQ ID NO:75), LAGAMVWAL (SEQ ID NO: 76), VWALDLDDF (SEQ ID NO:77) or LDLDDFQGS (SEQ ID NO:78). Indicated peptides can be used in treatment of destruction of joint cartilage caused by T-cells. Administration of pharmaceutical compositions based on indicated peptides can be used for induction of systemic immunological tolerance to autoantigens in attack of autoreative T-cells. Invention describes also pharmaceutical composition and test-kit comprising indicated peptides and diagnosis method of detection of activated autoreactive T-cells. EFFECT: valuable properties of peptides. 9 cl, 4 tbl, 1 ex