NOVEL PEPTIDES AS AUTOANTIGEN DERIVATIVES DESIGNATED FOR USE IN IMMUNOTHERAPY OF AUTOIMMUNE DISEASES Russian patent published in 2002 - IPC

FIELD: medicine, peptides. SUBSTANCE: invention relates to novel peptides derived form autoantigen HC_gp-39 being the indicated peptides have at least one of amino acid sequences: FGRSFTLAS (SEQ ID N 1), FTLASSETG (SEQ ID N 2), YDDQESVKS (SEQ ID N 3) AND FSKIASNTQ (SEQ ID N 4). These peptides simulate limiting T-cellular epitopes MHC of class 11 located on autoantigen HC_gp-39 in articular cartilage. HC_gp-39 and indicated peptides can be used in antigen-specific treatment of patients with destruction of articular cartilage in autoimmune disease to provide the tolerance of immune system. Autoantigen HC_gp-39 and indicated peptides are useful also for arthritis induction in nonhuman animals, especially in mice. Invention relates to also pharmaceutical compositions containing the indicated autoantigen and/or indicated peptides, method of diagnosis of detection of autoreactive T- cells and trial specimen and analytical set for use in method indicated above. EFFECT: new peptides indicated above, valuable medicinal properties. 15 cl, 4 dwg, 8 tbl, 2 ex