PIPERIZINYLPYRIDINE DERIVATIVES AS ANTI-OBESITY AGENTS Russian patent published in 2010 - IPC C07D213/74 C07D413/12 C07D213/75 C07D213/76 C07D401/12 A61K31/496 A61K31/5377 A61P3/04 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I) , where R is hydrogen or (lower)alkyl; R¹ is a (lower)alkyl or (C₃-C₇)cycloalkyl; X is nitrogen while Y is carbon or Y is nitrogen while X is carbon; m equals 0 or 1; Z is C(O) or SO₂; R² is selected from a group consisting of (lower)alkyl, (C₃-C₇)cycloalkyl or (C₃-C₇)cycloalkyl substituted with (lower)alkyl, (lower)phenylalkyl, where the phenyl ring is not substituted or is mono- or disubstituted with (lower)alkoxy or halide, pyridyl which is mono- or disubstituted with a halide, and NR³R⁴ or when Z is C(O), R² can also be a (lower)alkoxy; R³ is hydrogen or (lower)alkyl; R⁴ is selected from a group consisting of (lower)alkyl, (lower)alkoxyalkyl, (C₃-C₇)cycloalkyl, unsubstituted phenyl or phenyl which is mono-substituted with (lower)alkoxy, or (lower)phenylalkyl, where phenyl is not substituted or is mono- or disubstituted with a halide; or R³ and R⁴ together with the nitrogen atom to which they are bonded form a 5-, 6- or 7-member heterocyclic ring which optionally contains an additional heteroatom selected from oxygen, the said heterocyclic ring is unsubstituted or substituted with one or two groups independently selected from (lower)alkyl, halide and alkyl halide, or is condensed with a phenyl or cyclohexyl ring, and to their pharmaceutically acceptable salts, as well as to pharmaceutical compositions containing these compounds.

EFFECT: obtaining novel compounds and pharmaceutical compositions based on the said compounds, which are suitable for treating and/or preventing diseases which are associated with modulation of H3 receptors.

25 cl, 2 tbl, 93 ex