FIELD: chemistry.
SUBSTANCE: invention relates to new compounds of formula I 
where R1 is lower alkyl or C3-C7-cycloalkyl; X is C(O) or SO2; m equals 0 or 1; R2 is selected from a group consisting of lower alkyl, lower halogenalkyl, lower alkoxyalkyl, unsubstituted C3-C7-cycloalkyl, lower phenylalkyl, where phenyl is unsubstituted or mono- or disubstituted with lower alkyl, lower alkoxy, halogen or lower halogenalkyl, unsubstituted pyridyl or pyridyl which is mono- or disubstituted with lower alkyl, halogen or lower halogenalkyl, -NR3R4 or if X is C(O), R2 can also denote a lower alkoxy or lower alkoxyalkoxy, or if m equals 1, R2 can be unsubstituted phenyl or phenyl which is mono- or disubstituted with lower alkyl, lower alkoxy, halogen or lower halogenalkyl, , R3 is hydrogen or lower alkyl; R4 is selected from a group consisting of lower alkyl, C3-C7-pycloalkyl, C3-C7-cycloalkyl which is substituted with phenyl, lower C3-C7-cycloalkylalkyl, unsubstituted phenyl or phenyl which is mono- or disubstituted with lower alkyl, lower alkoxy, halogen or lower halogenalkyl, and lower phenylalkyl, where phenyl is unsubstituted or mono- or disubstituted with lower alkyl; or R3 and R4 together with the nitrogen atom to which they are bonded form a 4-, 5-, 6-, or 7-member heterocyclic ring system which optionally contains one more heteroatom selected from nitrogen, where the said heterocyclic ring system is unsubstituted or substituted with one, two or three groups independently selected from lower alkyl, halogen, halogenalkyl; and pharmaceutically acceptable salts of these compounds; except 2,2-dimethyl-N-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]propionamide. The invention also relates to a pharmaceutical composition for treating diseases which are associated with modulation of histamine H3 receptors based on formula I compounds.
EFFECT: new compounds which can be used to treat and/or prevent diseases associated with modulation of histamine H3 receptors are obtained and described.
21 cl, 105 ex, 2 tbl
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