FIELD: chemistry.
SUBSTANCE: invention relates to novel therapeutically suitable derivatives of pyridazin-3(2H)-one of formula 
and pharmaceutical compositions containing the said derivatives. These compounds are used for treating, preventing or inhibiting corresponding pathological conditions, diseases or disorders, mainly asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis or irritable colon syndrome.
EFFECT: obtaining compounds which are active and selective phosphodiesterase 4 (PDE4) inhibitors.
11 cl, 1 tbl, 182 ex
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