FIELD: chemistry.
SUBSTANCE: invention claims derivatives of pyridazin-3(2H)-one of formula 
(I), where R1, R2 and R4 are organic radicals described in the claim 1, R3 is cyclic group described in the claim, and R5 is phenyl or heteroaryl group described in the claim. Compounds of formula (I) inhibit phosphodiesterase 4 (PDE-4) and can be applied in treatment of various diseases or pathological states alleviated by PDE-4 inhibition, and in medicine production for treatment of aforesaid diseases. Also invention claims method of obtaining these compounds and intermediate compounds for their obtainment.
EFFECT: obtaining compounds which can be used in treatment of various diseases or pathological states and in medicine production for treatment of aforesaid diseases.
25 cl, 28 tbl, 243 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PYRIDAZINE 3(2H) DERIVATIVES AS INHIBITOR OF PHOSPHODIESTERASE 4 (PDE4), METHOD OF THEIR PREPARATION, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT | 2003 |
|
RU2326869C2 |
| PYRIDAZIN-3(2H)-ONE DERIVATIVES AND USE THEREOF AS PDE4 INHIBITORS | 2005 |
|
RU2386620C2 |
| DERIVATIVES OF PYRIDAZIN-3(2H)-ON AND THEIR APPLICATION AS INHIBITORS OF FDE4 | 2005 |
|
RU2376293C2 |
| CONDENSED TRIAZOLAMINES AS P2X7 MODULATORS | 2010 |
|
RU2533122C2 |
| NOVEL PIRIDAZONES AND TRIAZINONES FOR TREATMENT AND PREVENTING OF HEPATITIS B VIRUS INFECTION | 2015 |
|
RU2664329C1 |
| 1,1,1-TRIFLUORO-2-HYDROXY-3-PHENYLPROPANE DERIVATIVES | 2008 |
|
RU2481333C2 |
| PYRIDINONE AND PYRIDAZINONE DERIVATIVES | 2012 |
|
RU2632915C2 |
| AZABIPHENYLAMINOBENZOIC ACID DERIVATIVES AS DHODH INHIBITORS | 2008 |
|
RU2481334C2 |
| NEW ISOXAZOLIL ETHER DERIVATIVES AS PAM GABA A ALFA5 | 2019 |
|
RU2800160C2 |
| BICYCLIC PYRIDINE DERIVATIVES USEFUL AS FATTY ACID BINDING PROTEIN (FABP) 4 AND / OR 5 INHIBITOR | 2013 |
|
RU2648247C2 |
