PYRIDINONE PYRIDAZINONE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) Russian patent published in 2013 - IPC C07D237/14 C07D403/10 C07D403/12 C07D403/14 C07D401/10 C07D401/12 C07D401/14 C07D405/10 C07D471/04 C07D471/10 C07D487/04 C07D491/107 A61K31/50 A61K31/501 A61K31/5025 A61K31/551 A61P35/00 A61P29/00 A61P9/10 A61P13/12 A61P9/02 A61P3/10 A61P25/28 A61P27/02 A61P17/18 A61P43/00 

Abstract RU 2472782 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (IX) wherein radicals and symbols have values given in the claim, and pharmaceutically acceptable salts or tautomers thereof. Said compounds are inhibitors of poly(ADP-ribose)polymerase (PARP) and can be used to treat cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitisers for cancer treatment. The invention also relates to a pharmaceutical composition containing said compounds, use of said compounds and a method of treating said diseases.

EFFECT: high efficiency of using the compounds.

10 cl, 18 ex

Similar patents RU2472782C2

Title Year Author Number
PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS 2008
  • Branka Danila
  • Dessole Gabriehlla
  • Ferrin'O Federika
  • Dzhouns Filip
  • Kintsel' Olaf
  • Lillini Samuehle
  • Mural'Ja Ehster
  • Peskatore Dzhovanna
  • Shul'Tts-Fademrekht Karsten
RU2490265C2
INHIBITORS OF NONPRILYZINE 2011
  • Gendron Roland
  • Fleri Melissa
  • Khyuz Adam D.
RU2622288C2
SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS 2012
  • Fleri Melissa
  • Gendron Roland
  • Khjuz Adam D.
RU2604522C2
DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE 2009
  • Van Bin
  • Chu Dehniehl
RU2514937C2
PHTHALAZINE KETONE DERIVATIVE, METHOD OF OBTAINING THEREOF AND PHARMACEUTICAL APPLICATION 2011
  • Tan Pehn Cho
  • Li Sin'
  • Li Sjantsin'
  • Chehn' Jan
  • Van Bin'
  • Chzhu Chzhe
RU2564527C2
HETEROCYCLIC IMIDAZOLE COMPOUNDS, METHOD FOR THE PRODUCTION AND USE THEREOF 2016
  • Fan, Xing
  • Qin, Jihong
RU2686314C1
TRICYCLIC DERIVATIVE COMPOUND, METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SUCH A COMPOUND 2016
  • Lee, Hyunho
  • Chun, Kwangwoo
  • Joe, Bo-Young
  • Kim, Eun Seon
  • Jang, Eun Sung
  • Oh, Hyeongchan
  • Kim, Jeong-Min
  • Park, Jiseon
  • Lee, Hanchang
RU2715413C2
COMBINATIVE MEDICINAL AGENT 2003
  • Jasuda Nobujuki
  • Jamazaki Kazuto
RU2328280C2
POLYCYCLIC AGENTS FOR TREATING RESPIRATORY SYNCYTIAL VIRAL INFECTIONS 2004
  • Bond Sajlas
  • Sanford Vanessa Ann
  • Lambert Dzhon Nikolas
  • Lim Chin Ju.
  • Mitchell Dzheffri Piter
  • Drehffan Ehlister Dzhordzh
  • Nirn Roland Genri
RU2422444C2
CYCLIC CYANOENONE DERIVATIVES AS KEAP1 MODULATORS 2021
  • Altman, Michael
  • Candito, David, A.
  • Christian, Alec, H.
  • Di Pietro, Ornella
  • Lu, Min
  • Liu, Ping
  • Mansoor, Umar, Faruk
  • Mennie, Katrina, Marie
  • Musacchio, Andrew, J.
  • Palani, Anandan
  • Reutershan, Michael, H.
  • Shaw, David, Matthew
  • St-Gallay, Stephen
RU2822828C1

RU 2 472 782 C2

Authors

Dzhouns Filip

Kintsel' Olaf

Peskatore Dzhovanna

Llauger Bufi Laura

Shul'Tts-Fademrekht Karsten

Ferrin'O Federika

Dates

2013-01-20Published

2007-05-25Filed