MELANOCORTIN RECEPTOR MODULATORS, METHOD FOR PRODUCTION THEREOF AND USE THEREOF IN MEDICINAL AND COSMETIC PREPARATIONS FOR HUMAN USE Russian patent published in 2016 - IPC C07D401/12 C07D403/12 A61K31/4178 A61K31/454 A61K31/397 A61P17/00 A61P29/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, namely to heterocyclic compound of formula (I), as well as to its pharmaceutically acceptable salt and enantiomer, where R1 is a hydrogen atom, phenyl, linear saturated hydrocarbon chain containing 1-5 carbon atoms, cycloalkyl containing 5-6 carbon atoms, or straight saturated hydrocarbon chain containing 1-4 carbon atoms, substituted cycloalkyl containing 3 carbon atoms; R2 is hydrogen atom, hydroxyl, linear saturated hydrocarbon chain containing 1-5 carbon atoms, straight saturated hydrocarbon chain containing 1-4 carbon atoms, substituted cycloalkyl containing 3-7 carbon atoms, oxygen atom, substituted linear saturated hydrocarbon chain containing 1-4 carbon atoms, an oxygen atom, substituted carbonyl, substituted linear saturated hydrocarbon chain containing 1-4 carbon atoms, carbonyl, substituted linear saturated hydrocarbon chain containing 1-4 carbon atoms, or cycloalkyl containing 6 carbon atoms, carbonyl, substituted by oxygen atom, substituted linear saturated hydrocarbon chain containing 1-4 carbon atoms, Carbonyl, substituted monoalcylamino, alkyl which is linear saturated hydrocarbon chain containing 1 carbon atom, carboxyl group, cyano group or amino group, bisubstituted phenyl or linear hydrocarbon chain containing 1-4 carbon atoms; R3 is linear saturated hydrocarbon chain containing 1 carbon atom, substituted phenyl, possibly substituted with one or two groups, selected from halogen and oxygen, substituted linear saturated hydrocarbon chain containing 1 carbon atom; R4 is linear saturated hydrocarbon chain containing 1-4 carbon atoms, substituted imidazole, unsubstituted or substituted linear saturated hydrocarbon chain containing 1 carbon atom; R5 represents hydrogen atom or linear hydrocarbon chain containing 1-4 carbon atoms; X represents oxygen atom or sulphur atom; n, m equals to 1 or 2. Invention also relates to use of formula (I), pharmaceutical and cosmetic compositions based on compound of formula (I).

EFFECT: technical result is obtaining novel heterocyclic compounds, useful as modulators of melanocortin receptors.

21 cl, 2 dwg, 1 tbl, 26 ex