NAPHTHALENE DERIVATIVES SUITABLE FOR USE AS LIGANDS OF HISTAMINE 3 RECEPTORS Russian patent published in 2010 - IPC C07D205/04 C07D295/88 C07D217/06 C07D223/04 C07D295/192 A61K31/445 A61K31/397 A61K31/40 A61K31/495 A61K31/5375 A61K31/54 A61K31/55 A61P3/04 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to novel naphthalene derivatives of general formula I , as well as to their pharmaceutically acceptable salts, which can be used for treating and/or preventing diseases associated with H-3 receptor modulation. In formula I, R¹ is selected from hydrogen, lower alkyl, phenyl, phenyl-lower alkyl and lower alkoxyalkyl; R² is selected from hydrogen, lower alkyl, C₃-C₇-cycloalkyl, lower alkoxyalkyl or lower alkylsuphanylalkyl (all values of R¹ and R² are given in the formula of inventions); or R¹ and R² together with the nitrogen atom to which they are bonded form a 4-7-member saturated or partially unsaturated heterocyclic ring which can contain one more heteroatom selected from nitrogen, oxygen and sulphur atoms, where the said heterocyclic ring can be unsubstituted or substituted with 1-2 groups, or can be condensed with an unsubstituted phenyl ring; A is selected from (values of R³-R⁷, R⁹, R¹⁰, X, m, n, t, p, q and s are given in the formula of invention). Invention also pertains to a pharmaceutical composition containing formula I compounds.

EFFECT: increased effectiveness of application.

30 cl, 2 tbl, 188 ex