DERIVATIVES OF 1,1-DIOXOTHIOMORPHOLINYLINDOLYL METHANONE FOR USE AS HISTAMINASE MODULATORS Russian patent published in 2011 - IPC C07D401/12 C07D401/14 C07D403/12 C07D403/14 C07D417/12 C07D417/14 A61K31/404 A61K31/445 A61K31/54 A61P3/04 

FIELD: chemistry.

SUBSTANCE: invention describes compounds of formula I

, where R¹ is selected from a group comprising hydrogen, lower alkyl, lower hydroxyl, lower alkoxyalkyl, lower halogenalkyl, lower cyanoalkyl; unsubstituted or substituted phenyl; lower phenylalkyl, where the phenyl ring can be unsubstituted or substituted; and heteroaryl, selected from pyridyl and pyrimidinyl; R² denotes hydrogen or halogen; G denotes a group selected from

, where m equals, 0, 1; R³ is selected from lower alkyl, cycloalkyl and lower cycloalkylalkyl; n equals 0, 1; R⁴ denotes lower alkyl, as well as pharmaceutical compositions.

EFFECT: said compounds are used to treat or prevent diseases associated with histaminase receptor modulation.

19 cl, 1 tbl, 24 ex