KINASE MODULATORS BASED ON PYRROLOPYRIDINE DERIVATIVES Russian patent published in 2010 - IPC C07D471/04 A61K31/437 A61P29/00 A61P37/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to new compounds of formula where L¹ and L² independently denote a bond, -S-, -NH- or unsubstituted C₁-C₅alkylene; A¹ denotes a 6-member substituted aryl or unsubstituted heteroaryl; A² denotes aryl or heteroaryl; R¹ denotes halogen, -OR⁵, -NR⁶R⁷, -C(Z)R⁸, -S(O)_wR⁹, -CN, -NO₂, -S(O)₂NH₂, alkyl, aryl or heteroaryl; X¹ denotes -C(R²)=, -C(R²)(R³)-, -N(R⁴)- or -O-; R² and R³ independently denote hydrogen, -OR⁵ or alkyl; R⁴ denotes hydrogen or alkyl; Z denotes O or NH; w is integer from 0 to 2; R⁵ independently denotes hydrogen or alkyl; R⁶ and R⁷ independently denote hydrogen, -S(O)₂R¹¹ alkyl or heteroalkyl; R¹¹ denotes hydrogen or alkyl; R⁸ independently denotes hydrogen, -NR¹⁴R¹⁵, -OR¹⁶, heteroalkyl or cycloalkyl; R¹⁴, R¹⁵ and R¹⁶ independently denote hydrogen, alkyl, cycloalkyl, heteroalkyl or heterocycloalkyl; R⁹ independently denotes hydrogen or alkyl; and where R⁶ and R⁷, R¹⁴ and R¹⁵ independently and optionally together with the nitrogen atom to which they are bonded form a substituted or unsubstituted heterocycloalkyl. The invention also relates to a method of modulating protein kinase activity, as well as to use of compounds in paragraph 1 and a pharmaceutical composition based on the said compounds.

EFFECT: new compounds which can be useful in treating diseases mediated by kinase activity are obtained and described.

47 cl, 2 ex, 40 tbl