LIQUID DRUG RESERVOIRS Russian patent published in 2010 - IPC A61K9/10 A61K31/00 A61K47/08 A61K47/14 A61K47/22 A61J3/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds forming in vivo a biologically active drug reservoir composition which contains low-viscous nonliquid crystal mixtures of diacylglycerine, tocopherol, phosphatidylcholine and an oxygen-containing organic solvent where a bioactive agent is dissolved or dispersed in said mixture and where compounds form a liquid-crystal phase structure when contacting with a body fluid. Said compounds are applicable for preparing parenteral, non-parenteral and local slow-release drug reservoir compositions. The invention also covers a method of preparing and applying the compounds under the invention and to a method of the active agent delivery.

EFFECT: compounds under the invention provide prolonged controlled release of the active agent without "explosion" or "delay" effects in initial release.

34 cl, 8 dwg, 20 tbl, 48 ex