METHOD OF MEASURING HEAT PRODUCTION OF MICROORGANISMS IN FERMENTATION VESSEL IN CONTINUOUS AND PERIODIC PROCESSES AND FERMENTATION APPARATUS FOR REALISING SAID METHOD Russian patent published in 2010 - IPC C12Q3/00 G01K11/00 

FIELD: chemistry; biochemistry.

SUBSTANCE: proposed method can primarily be used in biotechnology, biochemistry and industrial microbiology. Fermentation apparatus are used to study growth and metabolism of microorganisms and for solving several other tasks. Proposed solution involves measurement within given time intervals of flow of liquid and gaseous media through a fermentation vessel at the beginning of the fermentation process and during the said process after selected time intervals necessary for measuring heat production of microorganisms and evaluating destabilising inputs of heat power from operation of apparatus for moving the culture fluid. Heat production is calculated as the increment of current values of heat power to the initial value of the measured heat power while making corrections for the effect of the said destabilising inputs. The method is realised in a fermentation apparatus in which a fermentation vessel is placed inside a controlled thermostating screen and is fitted with an additional mixing device for controlling temperature of the fermentation vessel. Pipes running to the fermentation vessel are in thermal contact with the controlled thermostating screen.

EFFECT: more accurate measurement of heat production of microorganisms in a fermentation vessel in continuous or periodic processes.

4 cl, 5 dwg, 1 tbl