INDAZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS Russian patent published in 2010 - IPC C07D231/56 C07D401/06 C07D405/12 C07D413/12 A61K31/416 A61K31/4245 A61K31/4439 A61P3/04 A61P3/10 A61P9/12 

Abstract RU 2392272 C2

FIELD: chemistry.

SUBSTANCE: invention refers to compounds of the formula (I) and pharmaceutically acceptable salts, where R1-R7 mean the same as provided in the invention description and claim. Compounds of the formula (I) are specific inhibitors of 11b-HSD1. They can be applied in treatment and/or prevention of diseases caused by dysfunctions related to 11b-HSD1 enzyme, particularly in treatment and/or prevention of metabolic diseases, obesity, dyslipidemia, hypertension and/or diabetes, especially diabetes type "П". Additionally subject matter includes pharmaceutical composition for treatment and/or prevention of the said diseases.

EFFECT: improved efficiency of derivatives.

21 cl, 1 tbl, 146 ex

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RU 2 392 272 C2

Authors

Amrajn Kurt

Kaj Tszjan'Pin

Gudnau Robert Alan Dzhr.

Khuntsiker Daniel'

Kun Bernd

Majveg Aleksander

Najdkhart Verner

Dates

2010-06-20Published

2005-09-21Filed