ARYLPYRIDINE DERIVATIVES Russian patent published in 2009 - IPC C07D401/12 C07D213/76 A61K31/435 A61P3/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula I

, where R¹ is hydrogen or alkyl; R² is hydrogen, alkyl or halogen; R³ is hydrogen, alkyl or halogen; R⁴ is phenyl or piperidinyl, optionally substituted with one or more substitutes, independently selected from alkyl, halogen, alkoxy, alkoxyalkyl, hydroxyalkoxy, trifluoromethyl, trifluoromethoxy, aryl, alkylcarbonylamino, alkoxycarbonylalkoxy and alkyl-SO₂-; R⁵ is hydrogen or alkyl; R⁶, R⁷, R⁸, R⁹ and R¹⁰ are independently selected from hydrogen, alkyl, halogen, trifluoromethyl, alkoxy and alkyl-SO₂; A is nitrogen or C-R¹⁰; E is nitrogen or C-R⁹; G is nitrogen or C-R⁸; where not more than one of A, E and G is nitrogen; and to their pharmaceutically acceptable salts and esters, as well as to a pharmaceutical composition with inhibitory activity towards enzyme 11beta-hydroxysteroid dehyrogenase 1 (11-beta-HSD1).

EFFECT: new compounds are obtained and described, which can be used in treating and preventing type II diabetes.

22 cl, 177 ex, 1 tbl