FIELD: chemistry.
SUBSTANCE: present invention relates to methods for synthesis of rivastigmine having formula (I), 
involving reacting 3-(1-dimethylaminoethyl)phenol of formula (V) 
or its S-enantiomer of formula (V-a) 
with carbonyl diimidazole, subsequent reaction of the reaction product with ethylmethylamine in an organic solvent to obtain a compound (II) 
or a compound (I) and optional splitting of the formula (II) compound to obtain a formula (I) compound or carry out a reaction of S-3-(1-dimethylaminoethyl) phenol of formula (V-a) with ethylmethyl carbamoylchloride in an inert organic solvent at high temperature and in the presence of a weak inorganic or organic base.
EFFECT: methods are cheap on an industrial scale and enable use of readily available industrially safe material.
22 cl, 1 dwg, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NEW METHOD OF THE N,N'-BIS[2-(1H-IMIDAZOL-4-YL)ETHYL]MALONAMIDE OBTAINING | 2018 |
|
RU2679636C1 |
| METHOD OF SYNTHESIS OF N-[2-(DIMETHYLAMINO)-ETHYL]-ACRIDINE-4- - CARBOXAMIDE AND ITS DERIVATIVES | 1997 |
|
RU2178785C2 |
| METHOD OF SYNTHESIS OF N,N-DISUBSTITUTED AMINOMETHYLSTYRENES OR ALPHA-AMINOMETHYLSTYRENES | 2014 |
|
RU2673231C1 |
| METHOD OF PRODUCING N-ALKYL-O-ARYL CARBAMATES | 2016 |
|
RU2637317C1 |
| METHOD OF PRODUCING R-N-[[3-[(DIMETHYLAMINO)CARBONYL]PYRIDIN-2-YL]SULPHONYL]CARBAMATES, IN WHICH SUBSTITUENT R IS METHYL OR ETHYL | 2023 |
|
RU2816572C1 |
| N-HYDROXYFORMAMIDE DERIVATIVE AND MEDICATION CONTAINING IT | 2011 |
|
RU2569851C2 |
| METHOD FOR OBTAINING 2-AMINO-N-(2,2,2-TRIFLUOROETHYL)ACETAMIDE | 2011 |
|
RU2581841C2 |
| METHOD OF PRODUCING N-METHYLCARBAMATES | 0 |
|
SU1433410A3 |
| METHOD OF PRODUCING N-SUBSTITUTED CARBAMIC ACID ESTER AND METHOD OF PRODUCING ISOCYANATE USING N-SUBSTITUTED CARBAMIC ACID ESTER | 2009 |
|
RU2528423C2 |
| METHOD FOR SYNTHESIS OF N-SUBSTITUTED SALICYLAMIDES | 2005 |
|
RU2411234C2 |
