FIELD: chemistry.
SUBSTANCE: method of the N,N'-bis[2-(1H-imidazol-4-yl) ethyl]malonamide of formula (I) obtaining by the dimethyl malonate with histamine reaction in the polar organic solvent at a temperature of 85–120 °C, comprising crystallization from the water and/or the polar organic solvent.
.
EFFECT: method allows to obtain a product with a purity of 99 wt% and is suitable for the substance production in the pharmaceutical industry.
6 cl, 6 dwg, 4 ex, 4 tbl
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