FIELD: chemistry.
SUBSTANCE: present invention relates to novel substituted 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines of general formula 1, their pharmaceutically acceptable salts and/or hydrates having serotonin 5-HT6 receptor antagonist properties. The compounds can be used in treating and preventing various diseases of the central nervous system, pathogenesis of which is associated with 5-HT6 receptors, particularly cognitive disorders, neurodegenerative diseases and psychiatric disorders. The compounds have anxiolytic and nootropic effect and can also be used for preventing and treating anxiety disorder and for enhancing metal capacity. In formula 1 
, R1 is a hydrogen atom, C1-C3 alkyl, (C1-C3)alkyloxy(C1-C3)alkyl, hydroxy(C1-C3)alkyl, pyridyl; R2 is a hydrogen atom, halogen atom, C1-C3 alkyl, phenyloxy or pyridyloxy; R3 is a hydrogen atom, C1-C3 alkyl, C1-C3 alkyloxy, (C1-C3)alkyloxy(C1-C3)alkyl, hydroxy(C1-C3)alkyl, pyridyl; R4 is C1-C3 alkyl; R5 is a hydrogen atom, one or two halogen atoms, C1-C3 alkyl, C1-C3 alkyloxy or hydroxyl; X is a sulphur atom or thionyl group (SO).
EFFECT: obtaining compounds which can be used in treating and preventing various diseases of the central nervous system.
24 cl, 9 dwg, 4 tbl, 19 ex
| Title |
Year |
Author |
Number |
| 2-ALKYLAMINO-3-ARYLSULFONYL-PYRAZOLO[1,5-a]PYRIMIDINES, SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS OF PRODUCING AND USING SAID COMPOUNDS |
2008 |
- Ivashchenko Aleksandr Vasil'Evich
- Savchuk Nikolaj Filippovich
- Ivashchenko Andrej Aleksandrovich
|
RU2393157C1 |
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2008 |
- Ivashchenko Aleksandr Vasil'Evich
- Savchuk Nikolaj Filippovich
- Ivashchenko Andrej Aleksandrovich
|
RU2393159C1 |
| SUBSTITUTED CYCLOALKANO[e OR d]PYRAZOLO[1,5-a]PYRIMIDINE-ANTAGONISTS OF SEROTONIN 5-HT RECEPTORS, METHOD OF PRODUCING SAID COMPOUNDS AND USE |
2008 |
- Ivashchenko Aleksandr Vasil'Evich
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|
RU2374249C1 |
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2006 |
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2013 |
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|
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2008 |
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|
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2008 |
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2008 |
- Ivashchenko Aleksandr Vasil'Evich
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|
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2008 |
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|
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2008 |
- Ivashchenko Aleksandr Vasil'Evich
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|
RU2399621C2 |
