FIELD: chemistry.
SUBSTANCE: invention relates to new 2-alkylsufanyl-3-arylsufonyl-cycloalkano[e]pyrazolol[1,5-a]pyrimidines of general formula 1 or 2-alkylsufanyl-3-arylsufonyl-cycloalkano[d]pyrazolo[1,5-a]pyrimidines of general formula 2, which are antagonist of 5-HT6 receptors. In compounds of formula 1
and 2 
,
R1 is a hydrogen atom or C1-C3 alkyl; R2 is C1-C3 alkyl; R3 is a hydrogen atom, one or two optionally identical halogen atoms, C1-C3 alkyl or hydroxyl, optionally substituted with C1-C3 alkyl; n is an integer equal to 1, 2 or 3.
EFFECT: compounds can be used in preventing and treating diseases of the central nervous system, anxiolytics and as compounds with nootropic effect and suitable for enhancing memory.
12 cl, 1 dwg, 4 tbl, 9 ex
| Title |
Year |
Author |
Number |
| SUBSTITUTED 2-ALKYLSULFANYL-3-SULFONYL-PYRAZOLO[1,5-a]PYRIMIDINES, SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS OF PRODUCING AND USING SAID COMPOUNDS |
2008 |
- Ivashchenko Aleksandr Vasil'Evich
- Savchuk Nikolaj Filippovich
- Ivashchenko Andrej Aleksandrovich
|
RU2393159C1 |
| 2-ALKYLAMINO-3-ARYLSULPHONYLCYCLOALKANO [e OR d]PYRAZOLO[1,5-a] PYRIMIDINES SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS FOR MAKING AND APPLYING THEREOF |
2008 |
- Ivashchenko Aleksandr Vasil'Evich
- Savchuk Nikolaj Filippovich
- Ivashchenko Andrej Aleksandrovich
|
RU2377244C1 |
| SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-a]PYRIMIDINES, SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS OF PRODUCING AND USING SAID COMPOUNDS |
2008 |
- Ivashchenko Aleksandr Vasil'Evich
- Savchuk Nikolaj Filippovich
- Ivashchenko Andrej Aleksandrovich
|
RU2393158C1 |
| TETRAHYDRO-PYRAZOLO[1,5-a]PYRIDO-PYRIMIDINES - SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS OF PRODUCING AND USING SAID COMPOUNDS |
2008 |
- Ivashchenko Aleksandr Vasil'Evich
- Kisil' Volodimir Mikhajlovich
- Savchuk Nikolaj Filippovich
- Ivashchenko Andrej Aleksandrovich
|
RU2391343C1 |
| SUBSTITUTED 4-SULPHONYL-PYRAZOLES AND 3-SULPHONYL-PYRAZOLO[1,5-a]PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT RECEPTORS, ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION, MEDICINAL AGENT AND METHOD OF OBTAINING THEM |
2008 |
- Ivashchenko Aleksandr Vasil'Evich
- Savchuk Nikolaj Filippovich
- Ivashchenko Andrej Aleksandrovich
|
RU2369600C1 |
| SUBSTITUTED 3,5-DIAMINO-4-SULFONYL-PYRAZOLES AND 2-AMINO-3-SULFONYL-PYRAZOLO-[1,5-a]PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT RECEPTORS, METHODS FOR THEIR PRODUCTION AND USE |
2008 |
- Ivashchenko Aleksandr Vasil'Evich
- Savchuk Nikolaj Filippovich
- Ivashchenko Andrej Aleksandrovich
|
RU2376291C1 |
| SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-a]PYRIMIDINE-2,6-DIAMINES, SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS OF PRODUCING AND USING SAID COMPOUNDS |
2010 |
- Ivashchenko Aleksandr Vasil'Evich
- Savchuk Nikolaj Filippovich
- Ivashchenko Andrej Aleksandrovich
|
RU2421456C1 |
| SUBSTITUTED 2-AMINO-3-SULFONYL-TETRAHYDRO-PYRAZOLO[1,5-a]PYRIDO-PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT RECEPTORS, METHODS OF PRODUCING AND USING SAID COMPOUNDS |
2008 |
- Ivashchenko Aleksandr Vasil'Evich
- Kisil' Volodimir Mikhajlovich
- Savchuk Nikolaj Filippovich
- Ivashchenko Andrej Aleksandrovich
|
RU2384581C2 |
| SUBSTITUTED 2-ALKYLMINO-3-SULFONYL-PYRAZOLO[1,5-a]PYRIMIDINES, SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS OF PRODUCING AND USING SAID COMPOUNDS |
2008 |
- Ivashchenko Aleksandr Vasil'Evich
- Savchuk Nikolaj Filippovich
- Ivashchenko Andrej Aleksandrovich
|
RU2399621C2 |
| (3-ARYLSULPHONYL QUINOLIN-8-YL-DIALKYL-AMINES - SELECTIVE SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF |
2012 |
- Ivashchenko Andrej Aleksandrovich
- Savchuk Nikolaj Filippovich
- Ivashchenko Aleksandr Vasil'Evich
|
RU2500672C1 |
