α- OR β-CRYSTALLINE MODIFICATIONS OF 5'-DESOXY-N-CARBOPENTYLOXY-5-FLUOROCYTIDINE, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS BASED ON SAID COMPOUNDS Russian patent published in 2010 - IPC C07H19/67 A61K31/7068 A61P35/00 

Abstract RU 2393164 C1

FIELD: chemistry.

SUBSTANCE: disclosed are α- and β-crystalline forms of 5'-desoxy-N4-carbopentyloxy-5-fluorocytidine of formula (III) , their preparation method through crystallisation of the raw product from a suitable solvent and pharmaceutical compositions based on the said compounds, having anti-cancer activity. The solvent used when preparing the α-modification is an ester or a mixture of ester-containing solvents. The solvent used when preparing the β-modification is a mixture of water and alkanol or a mixture of tetrahydrofuran and diethyl ether or carbon tetrachloride.

EFFECT: obtaining compounds and pharmaceutical compositions based on the said compounds, having anticancer activity.

10 cl, 2 dwg, 7 ex

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RU 2 393 164 C1

Authors

Skornjakov Jurij Vladimirovich

Smirnov Anatolij Gennad'Evich

Karapetjan Misak Karenovich

Fedorov Vladimir Egorovich

Perminov Sergej Vladimirovich

Ivanov Andrej Sergeevich

Dates

2010-06-27Published

2008-10-23Filed