N-OXYCARBONYL-SUBSTITUTED 5-DEOXY-5-FLUOROCYTIDINES AND PHARMACEUTICAL FORMULATION Russian patent published in 2012 - IPC C07H19/06 A61K31/70 

Abstract RU 2458932 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: there are described new N-oxycarbonyl-substituted 5'-deoxy-5-fluorocytidines of general formula I wherein R1 represents a saturated normal or branched hydrocarbon radical wherein a number of carbon atoms in the longest direct chain makes three to seven, or a redical of formula -(CH2)n-Y, wherein n = 0 - 4; provided Y represents cyclohexyl, or n = 2 - 4, provided Y represents phenyl; R2 represents a hydrogen atom. What is described is an anti-cancer preparation based on the compounds of formula T.

EFFECT: compounds show the excellent high-safety pharmacokinetic properties in treating tumours.

6 cl, 7 tbl

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RU 2 458 932 C2

Authors

Arasaki Motokhiro

Ishitsuka Khideo

Kuruma Isami

Miva Masanori

Murasaki Chikako

Shimma Nobuo

Umeda Isao

Dates

2012-08-20Published

1993-12-16Filed