NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Russian patent published in 2010 - IPC C07C233/55 C07C233/63 C07C233/81 C07C235/24 C07C311/13 C07C311/21 C07C317/50 C07C323/63 C07D207/327 C07D209/08 C07D209/34 C07D211/14 C07D211/32 C07D211/70 C07D213/55 C07D213/56 C07D213/81 C07D213/82 C07D249/18 C07D257/04 A61P19/02 A61K31/167 

FIELD: chemistry.

SUBSTANCE: invention relates to novel anthranilic acid derivatives having inhibitory effect on production of matrix metalloprotease 13 of formula 1 , where R¹ is a hydrogen atom or carboxy protective group selected from C_1-3alkyl; R² is phenyl, C_3-6cycloalkyl, saturated or unsaturated 5-6-member heterocyclic group containing 1-3 heteroatoms selected from N, O, S, which can be condensed with phenyl, which can be optionally substituted with C_1-6alkyl, C_1-6alkoxy, acetyl, acetoxy, halogen, halogenC_1-6alkyl, nitro group, hydroxyl group, CN, amino group, phenyl, saturated or unsaturated 5-6-member heterocyclic group containing 1-4 heteroatoms selected from N, O, S, which can be disubstituted with C_1-6alkyl; R³ is phenyl, C_3-6cycloalkyl, C₅cycloalkenyl, saturated or unsaturated 5-6-member heterocyclic group containing 1-3 heteroatoms selected from N, O, S, which can be condensed with phenyl (except benzoxazole), which can be optionally substituted with C_1-6alkyl, C_1-6alkoxy, phenyl, acetyl, halogen, halogenC_1-6alkyl, halogenC_1-6alkoxy, nitro group, hydroxyl group, hydroxyC_1-6alkyl, CN, acetylamino, ketone, phenoxy, benzoyl, benzyl, amino group, which can be disubstituted with C_1-6alkyl, carboxy group, C_1-6alkylsufonyl group or pyrrolyl; X¹ is a carbonyl group or sulfonyl group; X² is a C_1-3alkylene, C_2-3alkenylene or C_2-3alkynylene group which can be optionally substituted with C_1-3alkyl, or a bond; provided that when X¹ is a sulfonyl group and X⁴ is a bond, X² is a C_1-3alkylene, C_2-3alkenylene or C_2-3alkynylene group which can be optionally substituted with C_1-3alkyl; X³ is an oxygen atom or a bond; and X⁴ is a group with general formula -X⁵-X⁶- or -X⁶-X⁵-, where the bond on the left side of each formula is bonded to R³; and X⁵ is an oxygen atom, a sulphur atom, an imino group which can be optionally protected or a bond; X⁶ is a C_1-4alkylene, C_2-3alkenylene or C_2-3alkynylene group or a bond, as well as to their pharmaceutically acceptable salts. The invention also relates to a matrix metalloprotease 13 production inhibitor and a therapeutic agent for making a medicinal agent for treating rheumatoid arthritis.

EFFECT: possibility of making a medicinal agent for treating rheumatoid arthritis.

8 cl, 7 tbl, 633 ex