PYRIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS Russian patent published in 2009 - IPC C07D213/12 C07D213/59 C07D213/80 C07D401/12 C07D413/06 C07D213/55 C07D213/71 C07D213/82 C07D405/12 C07D413/12 C07D213/56 C07D213/75 C07D401/06 C07D409/12 C07F9/40 A61K31/275 A61K31/445 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention describes novel compound represented by formula I, where R¹ and R² are similar or different and each represents: (I) C_1-10alkyl group optionally substituted with 1-3 substituents selected from C_3-10cycloalkyl group, C_1-6alkoxycarbonyl group b C_1-6alkoxygroup; (2) C_6-14aryl group optionally substituted with 1-3 substituents selected from halogen atom, carboxyl group, C_1-6alkoxycabonyl group b carbamoyl group; or (3) C_7-13aralkyl group; R³ represents C_6-14aryl group optionally substituted with 1-3 substituents selected from C_1-6alkyl group, optionally substituted with 1-3 halogen atoms, halogen atom, C_1-6alkoxycarbonyl group, carboxyl group, hydroxy group, C_1-6alkoxygroup, optionally substituted with 1-3 halogen atoms; R⁴ represents amino group; L represents C_1-10alkylene group; Q represents bond, C_1-10alkylene group or C_2-10alkenylene group; and X represents: (1) hydrogen atom; (2) cyanogroup; (3) (3a) carboxyl group; (3b) carbamoyl group; and further as presented in invention formula. Invention also describes medication for treating diabetes, peptidase inhibitor, application of formula I compound, method of prevention or treatment of diabetes, method of peptidase inhibiting and method of obtaining formula I compounds.

EFFECT: obtaining novel compounds which have peptidase-inhibiting activity and are useful as medication for prevention and treatment of diabetes.

16 cl, 433 ex, 6 tbl