QUINOLINONE-CARBOXAMIDE COMPOUNDS AS AGONISTS OF 5-HT RECEPTORS Russian patent published in 2010 - IPC C07D451/04 A61K31/46 A61K31/4709 A61P1/00 

FIELD: medicine.

SUBSTANCE: in new compounds of the formula R¹ represents hydrogen, halogen; R² represents C_3-4 alkyl, or C_3-6 cycloalkyl; R3 represents hydrogen or C_1-3 alkyl; R⁴ represents -S(O)₂R⁶, or -C(O)R⁷; R⁵ represents hydrogen, C_1-3 alkyl, C_2-3 alkyl substituted with -OH or C_1-3alkoxy, or -CH₂-pyridyl; R⁶ represents C_1-3 alkyl, or R⁵ and R⁶ taken together form a C_3-4 alkylenyl; and R⁷ represents hydrogen, C_1-3 alkyl or pyridyl; or their pharmaceutically acceptable salts or solvates or stereoisomers. The invention also refers to pharmaceutical composition, to compounds application, to method for treating mammals, to method for treating disorders of reduced motor activity of gastrointestinal tract in a mammal, to method for obtaining compounds according to any of Clauses 1-12, to method for obtaining compounds of formula (I'), as well as to compounds of formula (III).

EFFECT: obtaining new biologically active compounds having activity as 5-NT₄ receptors.

24 cl, 29 ex, 4 tbl