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(19)

RU

(11)

2 689 777

(13)

C1

(51)

IPC

C07D471/04(2006-01-01)

C07D487/04(2006-01-01)

C07D498/04(2006-01-01)

C07D513/04(2006-01-01)

C07D519/00(2006-01-01)

A61K31/4184(2006-01-01)

A61K31/4188(2006-01-01)

A61K31/437(2006-01-01)

A61K31/5365(2006-01-01)

A61P9/00(2006-01-01)

A61P3/00(2006-01-01)

A61P25/00(2006-01-01)

A61P27/02(2006-01-01)

A61P29/00(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2016126655, 2014-12-08

(24)

Start date

2014-12-08

(22)

Actual filing date

2014-12-08

(45)

Published

2019-05-29

(72)

Inventor

Aleksander Rikki PiterKalmiano Mark DanielDefejs SabineDyure VeronikDelini MikhaelKher Yag PaulDzhekson Viktoriya ElizabetKeje ZhanKroplin BorisMak-Koss MalkolmSabnis Jogesh AnilSelbi Mattyu DankanSvinnen Dominik Lui LeonVan-Khautvin NataliChzhu ChzhaoninVener FolkmarKhajnelt Uve

(73)

Holder

Ucb Biopharma Sprl

CONDENSED TRICYCLIC BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY Russian patent published in 2019 - IPC C07D471/04 C07D487/04 C07D498/04 C07D513/04 C07D519/00 A61K31/4184 A61K31/4188 A61K31/437 A61K31/5365 A61P9/00 A61P3/00 A61P25/00 A61P27/02 A61P29/00 A61P35/00 

Abstract RU 2689777 C1

FIELD: chemistry.

SUBSTANCE: present invention relates to a novel compound of formula (I) or a pharmaceutically acceptable salt thereof, to a pharmaceutical composition containing the disclosed compounds, use of the disclosed compounds and a method of treating and / or preventing disorders. In formula I substitutes R1-R4, R5a, R5b, R6, X, Z are specified in the claim.

I.

EFFECT: disclosed is a compound possessing the TNFα activity inhibitor property.

23 cl, 241 ex

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RU 2 689 777 C1

Authors

Aleksander Rikki Piter

Kalmiano Mark Daniel

Defejs Sabine

Dyure Veronik

Delini Mikhael

Kher Yag Paul

Dzhekson Viktoriya Elizabet

Keje Zhan

Kroplin Boris

Mak-Koss Malkolm

Sabnis Jogesh Anil

Selbi Mattyu Dankan

Svinnen Dominik Lui Leon

Van-Khautvin Natali

Chzhu Chzhaonin

Vener Folkmar

Khajnelt Uve

Dates

2019-05-29—Published

2014-12-08—Filed

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