FIELD: medicine.
SUBSTANCE: claimed invention related to novel substituted propanamide derivatives of general formula 
(I'), as well as their pharmaceutically acceptable salts and based on them pharmaceutical compositions, which possess suppressive activity against bone resorption and reduction of bone density, reducing concentration of calcium in blood. Claimed invention also relates to application of compounds of general formula (I') or their pharmaceutically acceptable salts and based on them pharmaceutical compositions for production of medications. Values m, n and R5-R9 substituents are given in invention formula.
EFFECT: invention results in methods of bone resorption suppression and reduction of bone mass, reduction of calcium concentration in blood, as well as to method of prevention and treatment of metabolic bone disease.
28 cl, 4 tbl, 102 ex
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