PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS Russian patent published in 2018 - IPC C07D213/75 C07D401/12 A61K31/44 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to pyridone amide compounds of formula I and I'

where, independently for each case: G is

or ;

X is a bond or C₁-C₆ alkyl, wherein said C₁-C₆ alkyl is substituted with 0-6 halogen atoms, where up to two non-neighbouring CH₂ units of said C₁-C₆ alkyl can be substituted with -O-; R^x is absent, is H or C₃-C₈ cycloaliphatic group, where up to two non-neighbouring CH₂ units of the C₃-C₈ cycloaliphatic group can be substituted with -O- and said C₃-C₈ the cycloaliphatic group is substituted with 0-3 substituents selected from halogen and C₁-C₄ alkyl; R¹ is H, halogen, CN or C₁-C₆ alkyl, where said C₁-C₆ alkyl is substituted with 0-6 halogen atoms and where up to two non-neighbouring CH₂ units of said C₁-C₆ alkyl can be substituted with -O-; R² is H, halogen, CN or C₁-C₆ alkyl, wherein said C₁-C₆ alkyl is substituted with 0-6 halogen atoms, where up to two non-neighbouring CH₂ units of said C₁-C₆ alkyl can be substituted with -O-; R³ is H, halogen, CN or C₁-C₆ alkyl, wherein said C₁-C₆ alkyl is substituted with 0-6 halogen atoms, where up to two non-neighbouring CH₂ units of said C₁-C₆ alkyl can be substituted with -O-; R⁴ is H, halogen, CN or C₁-C₆ alkyl, where said C₁-C₆ alkyl is substituted with 0-6 halogen atoms, where up to two non-neighbouring CH₂ units of said C₁-C₆ alkyl can be substituted with -O-; R⁵ is H, halogen, CN or -X-R^x; R^5’ is H, halogen, CN or -X-R^x; R⁶ is H, halogen, CN or -X-R^x; R^6’ is H, halogen, CN or -X-R^x; R⁷ is H, halogen, CN or -X-R^x; R⁸ is a halogen or C₁-C₆ alkyl, where said C₁-C₆ alkyl is substituted with 0-6 halogen atoms, where up to two non-neighbouring CH₂ units of said C₁-C₆ alkyl can be substituted with -O-; p is an integer from 0 to 3, inclusively; and R⁹ is H or C₁-C₆ alkyl, where up to two non-neighbouring CH₂ units of said C₁-C₆ alkyl can be substituted with -O-.

EFFECT: invention relates to pharmaceutically acceptable salts used as inhibitors of sodium channels.

48 cl, 4 tbl, 30 ex