FIELD: chemistry.
SUBSTANCE: invention describes novel 1,2,3-triazole derivatives of general formula: , where X denotes O or N-OH; R1 is hydrogen, fluorine, chlorine, bromine, phenyl or C1-4-alkyl, unsubstituted or substituted 1-3 times with fluorine, chlorine and bromine; R2 - R5 hydrogen; pharmaceutically acceptable salts and stereoisomers thereof and a pharmaceutical composition containing the said compounds.
EFFECT: obtaining compounds which can be used as oestrogen receptor selective modulators for treating or preventing different conditions related to oestrogen function, including: bone loss, bone fracture, osteoporosis, metastatic bone disease, Piaget's disease, periodontal disease etc.
5 cl, 7 ex
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Authors
Dates
2010-07-20—Published
2005-12-05—Filed