OESTROGEN RECEPTOR MODULATORS Russian patent published in 2010 - IPC C07D249/16 C07D249/18 A61K31/41 A61P9/00 A61P35/00 

Abstract RU 2394820 C2

FIELD: chemistry.

SUBSTANCE: invention describes novel 1,2,3-triazole derivatives of general formula: , where X denotes O or N-OH; R1 is hydrogen, fluorine, chlorine, bromine, phenyl or C1-4-alkyl, unsubstituted or substituted 1-3 times with fluorine, chlorine and bromine; R2 - R5 hydrogen; pharmaceutically acceptable salts and stereoisomers thereof and a pharmaceutical composition containing the said compounds.

EFFECT: obtaining compounds which can be used as oestrogen receptor selective modulators for treating or preventing different conditions related to oestrogen function, including: bone loss, bone fracture, osteoporosis, metastatic bone disease, Piaget's disease, periodontal disease etc.

5 cl, 7 ex

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RU 2 394 820 C2

Authors

Grinli Mark L.

Mehn Dunfan

Sperbek Donald M.

Uildondzher Kennet Dzh.

Dates

2010-07-20Published

2005-12-05Filed