TRICYCLIC TRIAZOLIC COMPOUNDS Russian patent published in 2018 - IPC C07D498/14 A61K31/5383 A61P25/00

Abstract RU 2666728 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of general formula (I) wherein R₁ is benzyl optionally substituted by at least one halogen; -(C(R₃)₂)_m-heteroaryl group in which heteroaryl is a 5 or 6-membered heteroaryl radical containing 1–3 heteroatoms, selected from N or O, and is optionally substituted with at least one substituent selected from halogen, C_1-3-alkyl, C_1-3-alkoxy or C_1-3-haloalkyl; or -(C(R₃)₂)_n-heterocycloalkyl group in which the heterocycloalkyl group is a tetrahydropyranyl group or a tetrahydrofuranyl group; R₂ is phenyl optionally substituted with at least one substituent selected from halogen or C_1-3 haloalkyl; 5- or 6-membered heteroaryl radical containing 1–3 N atoms and optionally substituted with at least one substituent selected from halogen, C_1-3-alkyl or C_1-3-alkoxy; or a tetrahydropyranyl group; R₃ represents H or C_1-3 alkyl; m represents 1-3; and n represents 0-3. Invention also relates to preparation methods, to a pharmaceutical composition.

EFFECT: obtained are novel compounds of general formula (I) which can be used in the treatment or prophylaxis of a disease or condition mediated by a sigma receptor.

12 cl, 3 tbl, 22 ex

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RU 2 666 728 C2

Authors

Dias-Fernandes Khose-Luis

Almansa-Rosales Karmen

Kuevas-Kordobes Feliks

Dates

2018-09-12—Published

2014-04-21—Filed