[F-18] LABELLED L-GLUTAMIC ACID, [F-18] LABELLED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF, AS WELL AS SYNTHESIS METHOD THEREOF Russian patent published in 2010 - IPC C07C229/24 C07B59/00 C07C251/24 C07C309/73 C07C271/22 C07D207/16 A61K51/04 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula (I) which can be used in diagnosis of tumorous diseases. In formula (I) , A is OH, C₁-C₅ alkoxy, N(C₁-C₅ alkyl)₂, NH₂; G is OH, O-C₁-C₅ alkyl; R¹ and R² independently denote H, ¹⁸F, ¹⁸F-C₁-C₅ alkoxy, ¹⁸F-C₁-C₅ alkyl, provided that if one of the substitutes R¹ and R² contain an ¹⁸F isotope, the other does not. The invention also relates to compounds of formulae and which are used in synthesis of formula (I) compounds, as well as to use of compounds of formula (IV) in synthesis of compounds of formula (I) or (II).

EFFECT: obtaining novel compounds which can be used in diagnosis of tumorous diseases.

29 cl, 4 ex, 8 tbl, 4 dwg