FIELD: medicine; cardiology.
SUBSTANCE: group of inventions includes a method and pharmaceutical composition aimed at heartbeat number reduction of mammals. To that purpose a therapeutically effective dose of adenosine A1 receptor agonist represented by 6-(3-(R)-N-aminotetrahydrofuranyl)purine riboside (CVT-510) or 2-{6-[((lR,2R)-2-hydroxycyclopentyl)amino]purine-9-yl}(4S,5S,3R)-5-[(2-fluorphenylthio)methyl]oxolan-3,4-diol (CVT-3619) in combination with minimal therapeutically effective dose of beta-blocker.
EFFECT: efficient heartbeat frequency reduction due to synergic effect of administered compounds with minimal side effects.
22 cl, 7 tbl, 10 dwg, 6 ex
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