FIELD: chemistry.
SUBSTANCE: claimed invention relates to compound of formula I 
where m equals 0 or 1; R1 represents halogeno, (C1-6)alkyl, (C1-6)alkoxy, amino-(C2-6)alkoxy, (C2-6)alkylamino-(C2-6)alkoxy, di-[(C1-6)alkyl]amino-(C2-6)alkoxy, (C1-6)alkoxy-(C2-6)alkoxy, carbamoyl-(C1-6)alkoxy, N-(C1-6)alkylcarbamoyl-(C1-6)alkoxy, amino-(C1-6)alkyl, (C1-6)alkylamino-(C1-6)alkyl, di(C1-6)alkyl]amino-(C1-6)alkyl, carbamoyl-(C1-6)alkyl, N-(C1-6)alkylcarbamoyl-(C1-6)alkyl, (C1-6)alkoxy-(C2-6)alkylamino, heteroaryloxy, heterocyclyl-(C1-6)alkyl, heterocyclyloxy or heterocyclyl-(C1-6)alkoxy, and where any heteroaryl or heterocyclyl group in substituent R1 probably can have 1 or 2 substituents, selected from hydroxy, halogeno, (C1-6)alkyl, (C1-6)alkoxy, (C2-6)alkanoyl, hydroxy-(C1-6)alkyl, (C1-6)alkoxy-(C1-6)alkyl, and where any of determined above R1 substituents, which contains CH2 group bound with 2 carbon atoms, or group CH3, bound with an atom of carbon or nitrogen, probably can have on each said CH2 or CH3 group one or more substituents, selected from halogeno, hydroxy, amino, oxo, (C1-6)alkyl, (C2-6)alkenyl, (C2-6)alkinyl,. (C3-6)cycloalkyl, (C3-6)cycloalkoxy, (C1-6)alkoxy, (C1-6)alkoxy-(C1-6)alkyl, (C1-6)alkylsulphamoyl, heteroaryl, heteroaryl-(C1-6)alkyl and heterocyclyl, and where any heterocyclyl group in substituent R1 probably can have 1 or 2 oxo or tioxo substituents; R2 represents (C1-6)alkyl; R3 represents hydrogen; R4 represents (C3-6)cycloalkyl, (C1-6)alkyl or heteroaryl, and R4 probably can be substituted with one or more substituents, selected from halogeno, (C1-6)alkyl, (C1-6)alkoxy; and R5 represents hydrogen, halogeno or (C1-6)alkyl; or its pharmaceutically acceptable salt, to method of obtaining said compounds, to pharmaceutical composition for application in treatment of diseases mediated by based on them cytokines. Invention also relates to methods of inhibiting p38α-kinase enzymes, TNFα production and production of cytokines.
EFFECT: obtained and described are novel compounds, which can be applied in treatment of medical conditions mediated by cytokines.
14 cl, 31 ex, 9 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| AMIDE DERIVATIVES | 2004 |
|
RU2375352C2 |
| AMIDE DERIVATIVES CARRYING CYCLOPROPYLAMINOCARBONYL SUBSTITUTE, SUITABLE AS CYTOKINE INHIBITORS | 2004 |
|
RU2382028C2 |
| NOVEL 707 COMPOUNDS AND USE THEREOF | 2008 |
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RU2472781C2 |
| DERIVATIVES OF AMIDE, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT | 2000 |
|
RU2284187C2 |
| DERIVATIVES OF BENZAMIDE, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1999 |
|
RU2220951C2 |
| AMIDE DERIVATIVES | 2006 |
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RU2427575C2 |
| PYRAZINONE DERIVATIVES AND USE THEREOF IN TREATMENT OF LUNG DISEASES | 2008 |
|
RU2479580C2 |
| AMIDE DERIVATIVES, METHOD FOR PRODUCTION THEREOF (VARIANTS), PHARMACEUTICAL COMPOSITION AND INHIBITION METHOD | 2000 |
|
RU2260007C2 |
| DERIVATIVES OF BENZAMIDE, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1999 |
|
RU2215736C2 |
| P38 KINASE-INHIBITING ISOQUINOLINE DERIVATIVES | 2009 |
|
RU2512318C2 |
