METHOD FOR ESTIMATING LOCAL DRUG TOXICITY Russian patent published in 2010 - IPC G01N33/15 

FIELD: medicine.

SUBSTANCE: preparation is injected in a visual organ of a wakeful piglet. Before, eyelids are opened and hold open to choose an injection point in the visual organ; tissue damage is estimated by their temperature; drug temperature before injection is measured with using a thermal imaging unit; measurement is started before drug injection; drug temperature before injection is set equal to specified point temperature; the drug is injected once in the conjunctival cavity in a minimum single dose; then eyelids are released and separated again every second minute for duplicate temperature measurement; if observing hyperthermia in development for the first minutes after drug injection, the conjunctival cavity is rinsed with 0.9% normal saline with instilling a drop of 1% lidocaine hydrochloride and making a conclusion of high local toxicity and potential damage of the conjunctival epithelium.

EFFECT: invention allows improving safety, accuracy and rate of estimating local drug toxicity.

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