BICYCLIC KETONES AND METHODS OF THEIR USE Russian patent published in 2023 - IPC C07D487/04 C07D471/04 C07D498/04 A61K31/14 A61K31/437 A61K31/5365 A61P1/00 A61P17/06 A61P19/02 A61P25/16 A61P25/28 A61P29/00 

Abstract RU 2797922 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound having the general formula (I)

where R1, ring A and ring B are as described in the claims, which is used to inhibit the activity of RIP1 kinase, to a pharmaceutical composition containing this compound, to the use of this compound and to a method of treatment using this compound.

EFFECT: development of a new RIP1 kinase inhibitor useful for the treatment of diseases and disorders associated with inflammation, cell death and other causes.

28 cl, 2 tbl, 163 ex

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RU 2 797 922 C2

Authors

Patel, Snakhel

Gamilton, Gregori

Chzhao, Gujlin

Chen, Khuejfen

Daniels, Blejk

Stivala, Krejg

Dates

2023-06-13Published

2018-07-12Filed