FIELD: chemistry.
SUBSTANCE: invention relates to a novel orthorhombic crystalline form of trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrole-(Z)-2-butene dioate (asenapine), to methods of producing this crystalline form and to pharmaceutical compositions containing the orthorhombic crystalline form of asenapine.
EFFECT: said crystalline form and pharmaceutical compositions based on said crystalline form have potential in treating mental illnesses in mammals.
13 cl, 3 tbl, 17 ex, 2 dwg
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