FIELD: medicine.
SUBSTANCE: invention relates to spontaneously dispersed pharmaceutical compositions including substance P antagonist, 5-aryl-4(K)-arylcarbonylaminopent-2-enic acid, and carrier medium, including from 5 to approximately 85 wt % of lipophilic component, namely monoglycerides and diglycerides of C8-C10 fatty acids or purified with re-etherificated glycerol corn oil, and from 5 to approximately 90 wt % of surface active substance, namely l ether of polyethelene glycol and hydrogenised castor oil. Compositions by invention are stable and possess improved bioavailability.
EFFECT: invention also relates to methods of obtaining said compositions and methods of treating diseases which are cured with substance P antagonist, for instance respiratory diseases, intestinal disorders, enuresis and cough.
13 cl, 1 dwg, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ACYLAMINOALKENYLENEAMIDE DERIVATIVES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1997 |
|
RU2185375C2 |
| PRELIMINARY PREPARED EMULSION CONCENTRATES CONTAINING CYCLOSPORINE OR MACROLIDE | 1999 |
|
RU2235554C2 |
| PHARMACEUTICAL COMPOSITIONS COMPRISING CAMPTOTHECIN DERIVATIVE | 2012 |
|
RU2620331C2 |
| CYCLOSPORIN-CONTAINING AND PRACTICALLY OIL-FREE COMPOSITIONS | 2000 |
|
RU2249461C2 |
| NEW PHARMACEUTICAL COMPOSITIONS | 1999 |
|
RU2240121C2 |
| PHARMACEUTICAL COMPOSITIONS | 2011 |
|
RU2639482C2 |
| N-BENZOYLSTAUROSPORIN-CONTAINING SPONTANEOUSLY DISPERSING COMPOSITIONS | 2000 |
|
RU2266121C2 |
| ORAL PHARMACEUTICAL COMPOSITIONS BASED ON PRODUCTS CONTAINING LIPASES, FIRST OF ALL PANCREATINE, AND SURFACTANTS | 2005 |
|
RU2381813C2 |
| SELF-EMULSIFYING COMPOSITION FOR SCARCELY WATER-SOLUBLE MEDICAMENT | 1999 |
|
RU2257917C2 |
| COSMETIC AGENT FOR CARE AND MAINTENANCE OF NATURAL HAIR FUNCTION, CONTAINING 2-FURANON DERIVATIVE | 2001 |
|
RU2324470C2 |
