NOVEL COMPOUNDS WITH ANTIBACTERIAL ACTION Russian patent published in 2010 - IPC C07D413/14 C07D413/12 C07D405/14 C07D405/12 A61K31/538 A61K31/357 A61K31/435 A61P31/04 

FIELD: chemistry.

SUBSTANCE: present invention relates to organic chemistry, and specifically to compounds of general formula I , where A is an oxygen atom, an alkylene, alkenyl or hetero alkylene group, in which the CH₂ group is substituted with a NH group, where the said groups can be optionally substituted with OH, =O or CH₂OH groups, X¹, X², X³, X⁴ and X⁵ independently represent nitrogen atoms or groups of formula CH or CR⁴, Cy is cycloalkylene or heterocycloalkylene group containing at least one nitrogen atom, R¹ is a hydrogen atom, an alkyl or alkyloxy group, R² is a halogen atom, a hydroxy group, an alkyl or heteroalkyl residue, where the said groups can be optionally substituted with OH, NH₂ groups and/or a =O group, R³ is a group of formula -B-Y, in which B denotes an alkylene, alkenyl or heteroalkylene group, where the said groups can be optionally substituted with OH, NH₂, COOH groups or a =O group, and Y is an optionally substituted phenyl, optionally substituted heteroaryl group containing 5 or 6 ring atoms, or an optionally substituted bicyclic heterocycle in which one ring is phenyl or pyridyl, and the other is a 5-, 6- or 7-member heteroaryl or heterocycloalkyl group which contains up to 3 heteroatoms selected from nitrogen, oxygen and sulphur atoms, R⁴ is a halogen atom, n equals 0, 1 or 2 and m equals 0 or 1, or their pharmaceutically acceptable salts, solvates and hydrates. The invention also relates to a pharmaceutical composition based on the formula I compound and use of the compound or the pharmaceutical composition to treat bacterial infections.

EFFECT: obtaining novel compounds possessing useful biological properties.

12 cl, 7 ex