FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and pharmacology, namely to liquid compositions for treating hyperlipidemia, containing fenofibrate dissolved in an excipient which contains omega-3 fatty acid ether and ethanol, and optionally, a surface-active substance. Besides there is disclosed a method for improving fenofibrate solubility in omega-3 fatty acid ether that involves addition of ethanol to said omega-3 fatty acid ether, and also a methods of treating a patient suffering hyperlipidemia. Said improvement of fenofibrate solubility is ensured by the fact that the liquid compositions additionally contain ethanol in minimum amount 10 wt % of the composition weight. Besides a surface-active substance is optionally added to the liquid compositions specified above to ensure better digestion and reduced food intake effect.
EFFECT: improved bioavailability and higher effectiveness in small amount due to better fenofibrate solubility in omega-3 fatty acid ether.
27 cl, 32 tbl, 22 ex, 16 dwg
| Title |
Year |
Author |
Number |
| NOVEL PHARMACEUTICAL STATIN COMPOSITIONS AND TREATMENT METHODS CONNECTED WITH IT |
2005 |
- Guzman Gektor
- Al'Marsson Ehrn
- Remenar Dzhulius
|
RU2382642C2 |
| METHOD OF PRODUCING SODIUM SALT OF (4R,12AS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12A-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2826745C1 |
| METHOD OF PURIFYING COMPOUND (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-METHOXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12a-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2828091C1 |
| METHOD OF PURIFYING SODIUM (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12a-HEXAHYDRO-2H-PYRIDO-[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2828087C1 |
| METHOD OF PRODUCING SODIUM (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12a-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2828089C1 |
| METHOD OF PRODUCING (4R,12AS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12A-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE OF SODIUM |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2826748C1 |
| METHOD OF PURIFYING (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12a-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2828100C1 |
| METHOD OF PURIFYING (4R,12AS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12A-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE OF SODIUM |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2826759C1 |
| METHOD OF PURIFYING COMPOUND (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-METHOXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12a-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2828094C1 |
| METHOD OF PURIFYING (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-HYDROXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,12a-HEXAHYDRO-2H-PYRIDO[1',2':4,5]PYRAZINO[2,1-b][1,3]OXAZINE-9-CARBOXAMIDE |
2024 |
- Belyi Petr Aleksandrovich
- Lopatukhin Eduard Iurevich
- Korolev Vladimir Lvovich
- Zaslavskaia Kira Iakovlevna
- Belov Evgenii Iurevich
|
RU2828097C1 |
