NEW COMPOSITIONS OF FENOFIBRATE AND RELATED METHODS OF TREATING Russian patent published in 2010 - IPC A61K31/216 A61K47/10 A61K47/44 A61K9/10 A61K35/60 A61P3/06

Abstract RU 2398577 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine and pharmacology, namely to liquid compositions for treating hyperlipidemia, containing fenofibrate dissolved in an excipient which contains omega-3 fatty acid ether and ethanol, and optionally, a surface-active substance. Besides there is disclosed a method for improving fenofibrate solubility in omega-3 fatty acid ether that involves addition of ethanol to said omega-3 fatty acid ether, and also a methods of treating a patient suffering hyperlipidemia. Said improvement of fenofibrate solubility is ensured by the fact that the liquid compositions additionally contain ethanol in minimum amount 10 wt % of the composition weight. Besides a surface-active substance is optionally added to the liquid compositions specified above to ensure better digestion and reduced food intake effect.

EFFECT: improved bioavailability and higher effectiveness in small amount due to better fenofibrate solubility in omega-3 fatty acid ether.

27 cl, 32 tbl, 22 ex, 16 dwg

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RU 2 398 577 C2

Authors

Al'Marsson Ehrn

Ratanabanangkoon Pasut

Remenar Dzhulius

Guzman Gektor

Dates

2010-09-10—Published

2005-08-04—Filed