FIELD: medicine.
SUBSTANCE: there are produced multipurpose and polyvalent inhibitors prepared of fused proteins containing polypeptide which identifies and blocks a functional site of molecule involved in angiogenesis, and polypeptide containing oligomerisation domain and a functional site modulating or inhibiting angiogenesis and separated by a proteinase sensitive site.
EFFECT: inhibitors are suitable for treatment and prevention of the pathologies caused by angiogenesis, eg a malignant tumour, rheumatoid arthritis or psoriasis.
25 cl, 6 dwg, 1 tbl, 1 ex
| Title |
Year |
Author |
Number |
| HOMODIMERIC FUSED PROTEIN WITH ACTIVITY OF ANGIOGENESIS INHIBITOR (VARIANTS), DNA MOLECULE ENCODING HOMODIMERIC FUSED PROTEIN, VECTOR FOR EXPRESSION OF HOMODIMERIC FUSED PROTEIN, METHOD FOR TRANSFECTION OF MAMMALIAN CELL AND METHOD FOR PREPARING HOMODIMERIC FUSED PROTEIN |
1999 |
- Lo Kin-Ming
- Li Jue
- Dzhilliz Stefen D.
|
RU2240328C2 |
| FUSED MOLECULE CAPABLE OF INDUCING NON-INFLAMMATORY PHAGOCYTOSIS |
2022 |
- Kim, Chan Hyuk
- Chung, Won Suk
- Jung, Hyun Cheol
- Lee, Se Young
|
RU2823919C1 |
| FUSED PROTEIN, NANOPARTICLE CONSISTING OF PLURALITY OF MONOMERS OF SAID FUSED PROTEIN, AND USE THEREOF |
2015 |
- Ceci, Pierpaolo
- Falvo, Elisabetta
|
RU2714155C2 |
| E. coli BL21 (DE3)/pTEV-TMS STRAIN - FUSION PROTEIN TrxTEVrs-TMS PRODUCER, DESTINED FOR PROTEOLYTIC CLEAVAGE WITH TUMSTATIN ANTI-ANGIOGENIC PEPTIDE FORMATION, HUMAN TUMSTATIN FRAGMENT [L69K-95] DERIVATIVE, AND METHOD FOR RECOMBINANT ANTI-ANGIOGENIC PEPTIDE PRODUCTION |
2015 |
- Esipov Roman Stanislavovich
- Kostromina Mariya Andreevna
- Bejrakhova Kseniya Andreevna
- Makarov Dmitrij Aleksandrovich
- Miroshnikov Anatolij Ivanovich
|
RU2625008C2 |
| CHIMERIC ANTIGENE RECEPTOR |
2019 |
- Pyule, Marten
- Kordoba, Shon
- Tomas, Sajmon
- Onuokha, Simobi
- Chin Lim, Ven
- Ma, Byao
- Ferrari, Mate
|
RU2810092C2 |
| THERAPEUTIC FUSION PROTEINS |
2012 |
- Cheddok Dzhon
- Kharper Elejn
|
RU2651492C2 |
| IL-12 COMPOSITIONS AIMED AT EDB |
2019 |
- Villa, Alessandra
- Matasci, Mattia
- Ongaro, Tiziano
|
RU2758143C1 |
| COMPOSITIONS OF HUMANISED NOTCH FUSED PROTEINS AND METHODS OF TREATING |
2008 |
- Kitadzhevski,Jan
- Shober,Kerri
|
RU2532830C2 |
| NUCLEOTIDE SEQUENCE ENCODING FUSED PROTEIN CONSISTING OF SOLUBLE EXTRACELLULAR FRAGMENT OF HUMAN Dll4 AND CONSTANT PART OF HEAVY CHAIN OF HUMAN IgG4 |
2021 |
- Aksenova Anna Yurevna
- Volkov Kirill Vladimirovich
- Voronina Ekaterina Vladimirovna
- Marygin Roman Andreevich
- Askretkov Aleksandr Dmitrievich
- Zavarzin Aleksej Alekseevich
- Lukyanov Dmitrij Valerevich
- Shevchenko Konstantin Georgievich
- Sajfitdinova Alsu Faritovna
- Semenikhin Vyacheslav Alekseevich
|
RU2787060C1 |
| BIFUNCTIONAL BINDING POLYPEPTIDES |
2019 |
- Bossi, Dzhovanna
- Reis, Karlos
- Tavar, Radzhivkumar
- Karnok, Adam
- Smit, Nikola
|
RU2806747C2 |
