FIELD: biotechnology.
SUBSTANCE: invention relates to a chimeric antigen receptor (CAR) that binds B-cell maturation antigen (BCMA), as well as a nucleic acid expression construct and a cell containing a nucleic acid molecule encoding the said CAR. A vector containing the above expression construct is also disclosed. The invention also relates to a method of producing a cytolytic immune cell having the ability to kill a target cell expressing BCMA, as well as a composition containing the above cell.
EFFECT: invention is effective for the treatment of cancer.
14 cl, 13 dwg, 2 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CELL | 2014 |
|
RU2717984C2 |
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|
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|
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