FIELD: chemistry.
SUBSTANCE: invention discloses a method of producing isotope-modified peptides and proteins, based on introduction of a stable 18O isotope (isotopic tag) into carboxyl groups of peptides and proteins by holding in a solution simultaneously containing H2 18O and trifluoroacetic acid.
EFFECT: method enables to obtain isotope-modified tags which are resistant to destruction and suitable for quantitative mass-spectrometric analysis with retention of the initial structure of the analysed compounds.
1 dwg, 3 ex
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