2,4-DI(PHENYLAMINO)PYRIMIDINES, APPLIED IN TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY DISORDERS AND IMMUNE SYSTEM DISORDERS Russian patent published in 2010 - IPC C07D239/48 C07D405/12 C07D403/12 C07D401/12 C07D401/14 A61K31/506 A61K35/00 A61P29/00 A61P37/00 

FIELD: medicine.

SUBSTANCE: invention relates to novel pyrimidine derivatives of formula (I) or their pharmaceutically acceptable salts which possess inhibiting activity with respect to focal adhesion kinase (FAK), proteintyrosinekinase ZAP-70, receptor of insulin-like growth factor 1 (IGF-1R), tyrosinekinase activity of anaplastic lymphoma (ALK) and fusion protein NPM-ALK. In formula (I) , R⁰, R¹ and R² independently represent hydrogen, C₁-C₈ alkyl, 5- or 6-member heterocycle, containing 1,2 or 3 heteroatoms, selected from N, O and S, C₁-C₈alkoxy group, C₁-C₈alkylsulphinyl, C₁-C₈alkylsulphonyl, C₅-C₁₀arylsulphonyl, halogen, carbamoyl, sulphamoyl, etc.; R³ represents C₁-C₈alkylsulphinyl, C₁-C₈alkylsulphonyl, C₅-C₁₀arylsulphonyl, carbamoyl or sulphamoyl; R⁴ represents hydrogen or C₁-C₈alkyl; R⁵ represents chlorine or bromine; R⁶ represents hydrogen; R⁷, R⁸, R⁹ and R¹⁰ independently represent C₁-C₈alkyl, C₅-C₁₀aryl, possibly substituted by 5- or 6-member heterocycle, containing 1, 2 or 3 heteroatoms, selected from N, O and S, where substituents are selected from C₁-C₈alkyl, hydroxy, hydroxy-C₁-C₈alkyl, C₁-C₈alkoxy C₁-C₈alkyl, cyano, oxo, C₁-C₈alkylamino, diC₁-C₈alkylamino, carbamoyl, C₁-C₈alkylcaronyl, 5-10-member heterocycle, containing 1, 2 or 3 heteroatoms, selected from N and O, which is probably substituted by C₁-C₈alkyl; C₁-C₈alkoxy group, halogen- C₁-C₈alkoxy group, etc; A represents C. Invention also relates to pharmaceutical composition and to application of compounds of formula (I) for preparation of medication.

EFFECT: novel compounds possess useful biologic activity.

15 cl, 61 ex