NOVEL TRICYCLIC DERIVATIVES (VARIANTS), PHARMACEUTICAL COMPOSITION (VARIANTS), METHOD FOR INHIBITION OF IMMUNE RESPONSE OR TREATMENT AND/OR PROPHYLAXIS OF ALLERGIC DISEASES (VARIANTS) Russian patent published in 2003 - IPC

Abstract RU 2216533 C2

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel tricyclic derivatives of formulas (I) , (Ia') , (Ib') , (Ig') , (If') , their salts and hydrates that show immunosuppressive or anti-allergic effect, to pharmaceutical compositions based on thereof and to method for inhibition of immune response or treatment and/or prophylaxis of allergic diseases. Novel compounds correspond to the general formula (I) wherein each of rings A, B and C represents independently optionally substituted aromatic carbocycle or optionally substituted 5- or 6-membered heterocycle that can be condensed with benzene ring; W1,W2 and/or W3 represent a bond if ring A, ring B and/or ring C is optionally substituted heterocycle; X means O-, -CH2-,-NR1- wherein R1 means hydrogen atom, optionally substituted lower alkyl, lower alkenyl, lower alkylcarbonyl or optionally substituted lower alkoxycarbonyl or -S(O)p wherein p = 0- 2; Y means hydrogen atom, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted lower alkoxycarbonyl, optionally substituted sulfamoyl, optionally substituted amino-group, optionally substituted aryl or optionally substituted 5- or 6-membered heterocycle and others. EFFECT: valuable medicinal properties of compounds. 50 cl, 142 tbl

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RU 2 216 533 C2

Authors

Tanimoto Norikhiko

Khasegava Jasushi

Khaga Nobukhiro

Dates

2003-11-20Published

1999-01-26Filed