PHENYL DERIVATIVES AS PPAR AGONISTS Russian patent published in 2009 - IPC C07D213/38 C07D213/30 C07D213/32 C07D213/46 C07D213/56 C07D213/75 C07D213/82 C07D237/08 C07D239/26 C07D239/28 C07D241/12 A61K31/44 A61K31/435 A61K31/505 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula and to their pharmaceutically acceptable salts or esters, where X¹ is O, S, CH₂; R¹ is hydrogen; R² is hydrogen or C₁-C₇alkyl, R³ is hydrogen or C₁-C₇alkyl; R⁴ and R⁸ are independently hydrogen, C₁-C₇alkyl, C₁-C₇alkoxy-C₁-C₇alkyl, fluoroC₁-C₇alkyl; R⁵, R⁶ and R⁷ are independently hydrogen, C₁-C₇alkyl, halogen, fluoroC₁-C₇alkyl; and one or R⁵, R⁶ and R⁷ represents , where X² is S, O, NR⁹, (CH₂)_PNR⁹CO or (CH₂)_PCONR⁹, R⁹ is hydrogen, C₁-C₇alkyl; one or two of Y¹, Y ², Y³ and Y⁴ is N, and the rest represent C-R¹² R¹⁰ is C₁-C₇alkyl, C₃-C₇ cycloalkyl; R¹¹ is hydrogen; R¹² in each case is independently selected from hydrogen, C₁-C₇alkyl, C₃-C₇ cycloalkyl, fluoroC₁-C₇ alkyl, C₁-C₇alkoxy-C₁-C₇alkyl, hydroxyC₁-C₇alkyl, di-C₁-C₇alkylamino-C₁-C₇alkyl; R¹³ is phenyl or heteroaryl, which is a 6-member aromatic ring, containing nitrogen as a heteroatom, which can be substituted with a CF₃ group, lower fluroalkoxy group or halogen; m=0 or 1, n=0, 1, 2, and p=0, 1 or 2, and the sum of m, n and p=1, 2, 3 or 4; under the condition that, there are no formula I compounds, where X¹ is O, R² and R³ are hydrogen; R⁶ is , X² is O or S, and m=0. The invention also relates to pharmaceutical compositions containing such compounds, with agonistic activity towards PPARδ and/or PPARα.

EFFECT: obtaining compounds for pharmaceutical compositions, with agonistic activity towards PPARδ and/or PPARα.

28 cl, 155 ex