FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formula (I) in form of base or a pharmaceutically acceptable addition salt with an acid. The disclosed compounds have β-amyloid peptide(β-A4) formation inhibiting properties. In formula 
(I), R1 denotes: C1-6-alkyl or phenyl; where said phenyl groups are substituted with two substitutes selected from halogen atoms; R1 and R2' independently denote a hydrogen atom or a hydroxy group; R3 denotes C1-6-alkyl; one or another of radicals R4 and R5 is a group Z 
and one or another of radicals R4 and R5 is a -C(X)R6 group; G denotes a single bond; Y denotes a single bond, an oxygen atom, a sulphur atom, a C1-4-alkylene group; A and B independently denote a hydrogen atom, a halogen, trifluoromethyl, trifluoromethoxy group; provided that if Y denotes a single bond or an oxygen atom and if group Z is a 
type group, A does not denote a hydrogen atom; X denotes an oxygen atom; R6 denotes a C1-6alkoxy group. The invention also relates to a method for synthesis of formula (I) compounds, to a medicinal agent and a pharmaceutical composition based on said compounds, and to use of formula (I) compounds in preparing the medicinal agent.
EFFECT: increased effectiveness of using said derivatives.
6 cl, 1 tbl, 31 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND APPLICATION AS INHIBITORS OF B-AMILOYD PEPTIDES PRODUCTION | 2004 |
|
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| THIENOPYRIMIDINE DERIVATIVES, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION AND METHOD FOR ANTAGONIZATION OF GONADOTROPIN-RELEASING HORMONE | 2000 |
|
RU2233284C2 |
| INDOLE DERIVATIVE | 2007 |
|
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| (HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS | 2012 |
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| DERIVATIVES OF AMINOQUINOLINE AND AMINOPYRIDINE AND THEIR USING AS ADENOSINE LIGANDS A | 2002 |
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| USING EP4 RECEPTOR ANTAGONISTS IN TREATING IL-23-MEDIATED DISEASES | 2011 |
|
RU2571816C2 |
| BRANCHED ALKYLAMINO DERIVATIVES OF THIAZOLE OR THEIR POTENTIAL STEREOISOMERS OR THEIR ADDITIVE SALTS WITH MINERAL OR ORGANIC ACID, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION HAVING ACTIVITY IN RESPECT WITH FACTOR OF RELEASING OF CORTICOTROPIC HORMONE AND ALKYLAMINO DERIVATIVES OF THIAZOLE AS INTERMEDIATE COMPOUNDS | 1993 |
|
RU2102389C1 |
| ARYLALKYLCARBAMATE DERIVATIVES, SYNTHESIS AND USE THEREOF IN THERAPY | 2004 |
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RU2400472C2 |
| CYCLIC PEPTIDE DERIVATIVES OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITION | 1993 |
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RU2129562C1 |
| DERIVATIVES OF AMINOQUINOLINE AND THEIR USING AS ADENOSINE A3 LIGANDS | 2004 |
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RU2317290C2 |
