BRANCHED ALKYLAMINO DERIVATIVES OF THIAZOLE OR THEIR POTENTIAL STEREOISOMERS OR THEIR ADDITIVE SALTS WITH MINERAL OR ORGANIC ACID, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION HAVING ACTIVITY IN RESPECT WITH FACTOR OF RELEASING OF CORTICOTROPIC HORMONE AND ALKYLAMINO DERIVATIVES OF THIAZOLE AS INTERMEDIATE COMPOUNDS Russian patent published in 1998 - IPC

FIELD: chemistry of heterocyclic compounds; pharmacology. SUBSTANCE: branched alkylamino derivatives of thiazole have formula I given in specification where R₁ is naphthyl or radical having formula A₁, where X,Y,Z are hydrogen, halogen, C₁-C₅-alkoxy, C₁-C₅-alkyl, hydroxy, nitro or trifluoromethyl; R₂ is hydrogen, halogen, C₁-C₅-alkyl, hydroxymethyl or formyl; R₃ is C₁-C₅-alkyl, C₃-C₈-cycloalkyl, C₂-C₆-alkenyl, C₄-C₈-cycloalkyl alkyl or phenyl; R₄ is hydrogen; R₅ is C₁-C₅-alkyl, C₃-C₈-cycloalkyl being optionally substituted by C₁-C₅-alkyl, C₄-C₈-cycloalkyl alkyl, C₂-C₆-alkenyl or radical having formula B where p=0,1,2 or 3; R₆ is optionally substituted phenyl, pyridyl, imidazolyl or C₃-C₈-cycloalkyl, or thienyl; m, n is 0 or 1. Alkylamino derivatives of thiazole having formula IV where R₁ is phenyl which is optionally substituted by halogens, is C₁-C₅-alkyl, R₅ is C₁-C₅ alkyl or C₃-C₈-cycloalkyl, is phenyl or pyridyl are used as intermediates for synthesis compounds with formula I. EFFECT: improved quality of product; improved efficiency of the method.